The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

Author: JJ Virgin February 18, 2026 Duration: 50:22
How do ultra-processed foods change the way your genes behave? In this episode, I talk with my longtime friend and mentor, Dr. Jeffrey Bland, about why ultra-processed foods may be the most dangerous health experiment humans have ever run. We explored how food acts as information—shaping gene expression, immune health, and even how full or satisfied you feel. Dr. Bland, often called the father of functional medicine, brings decades of insight into how modern food systems are quietly rewriting our biology. Dr. Jeffrey Bland is known as the father of functional medicine and has spent over five decades studying how food, lifestyle, and biology shape human health. He’s a prolific educator, researcher, and founder behind multiple institutes, including Big Bold Health, dedicated to personalized and preventive medicine. What you’ll learn: (02:44) Why ultra-processed foods may be the biggest driver of modern chronic disease. (04:32) How food functions as biological information that influences gene expression. (06:49) Why life expectancy is declining despite advances in modern medicine. (09:22) How ultra-processed foods disrupt the gut microbiome and immune system. (17:38) What distinguishes healthy gut bacteria from harmful microbial patterns. (24:39) Why poor satiety from processed foods fuels weight gain and GLP-1 drug use. (28:29) How bitter compounds in natural foods naturally stimulate satiety hormones. (39:39) One simple mindset shift that can immediately improve food choices and health. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/bold → Fatty15 | Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness - especially as you age. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/VIRGINWELLNESS and using code VIRGINWELLNESS at checkout. Learn more about your ad choices. Visit megaphone.fm/adchoices

Midlife isn't a crisis; it's a catalyst. On Well Beyond 40, JJ Virgin guides a conversation about rewriting the narrative of aging for women, moving from simply coping to truly thriving. This isn't about chasing youth, but about building a foundation of strength and vitality that makes the coming decades the most rewarding yet. Each episode feels like a direct, practical talk with a trusted expert who cuts through the noise. You'll hear actionable strategies rooted in science, focusing on how nutrition, movement, and mindset intersect uniquely during this life stage. JJ translates complex research into clear steps for refueling your body, managing energy, and cultivating a sense of purpose that goes far beyond the scale. The Well Beyond 40 podcast operates on the principle that knowing *why* something works is just as important as knowing *what* to do. Listeners are invited into a space where questions about metabolic shifts, hormonal balance, sustainable fitness, and intentional beauty are met with evidence-based answers and genuine empathy. It’s a resource for any woman ready to move past generic advice and discover what it means to age with power, confidence, and joy on her own terms. Tune in to reframe your approach and build a life that feels truly well-lived.
Author: Language: English Episodes: 100

Well Beyond 40
Podcast Episodes
Recharge and Reset: Recovery, Hormones, and Advanced Fat-Loss Hacks [not-audio_url] [/not-audio_url]

Duration: 26:23
Are you unknowingly sabotaging your metabolism by skipping recovery or getting poor sleep? In this episode, I take you beyond diet and exercise to reveal the real fat-loss accelerators—sleep, recovery, hormones, and mind…
How to Rewire Your Brain for Lasting Health with John Assaraf [not-audio_url] [/not-audio_url]

Duration: 55:21
How can neuroscience and self-talk help you break old habits and form empowering ones? In this episode, I sit down with my longtime friend and mindset expert John Assaraf to explore the neuroscience of transformation—how…
Move to Boost: Exercise Strategies to Ignite Your Metabolism [not-audio_url] [/not-audio_url]

Duration: 18:41
How can you exercise smarter after 40 to burn fat, build muscle, and keep your metabolism strong? In this episode, I break down how to exercise smarter—not harder—so you can ignite your metabolism after 40. I share the t…
Food as Fuel: Eating to Reignite Your Metabolism [not-audio_url] [/not-audio_url]

Duration: 24:01
If you’ve been unintentionally slowing down your metabolism by eating the wrong foods, what can you do about it? In this episode, I’ll show you how to use food as fuel to reignite your metabolism—especially during midlif…
Muscle-First Metabolism: The Key to Midlife Weight Loss for Women 40+ [not-audio_url] [/not-audio_url]

Duration: 17:55
Join me, JJ Virgin, in this 5-part series where each episode tackles the real reasons weight loss stalls in midlife, from muscle loss and food choices to exercise, hormones, stress, and recovery. This series is about rec…
What Your Plate Should Look Like for Fat Loss [not-audio_url] [/not-audio_url]

Duration: 34:25
In this episode, I break down the science of building a fat-loss-friendly plate. I share why protein is your anchor, why fiber is a game changer, and how healthy fats and slow, low carbs keep your body satisfied and your…
Lose Your Mind to Reclaim Your Health with Josh Pais [not-audio_url] [/not-audio_url]

Duration: 46:27
How can you transform stress and anxiety into creative energy? In this episode, JJ Virgin talks with actor, teacher, and author Josh Pais to explore the surprising connections between emotions, health, and creativity. Jo…