The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

Author: JJ Virgin February 18, 2026 Duration: 50:22
How do ultra-processed foods change the way your genes behave? In this episode, I talk with my longtime friend and mentor, Dr. Jeffrey Bland, about why ultra-processed foods may be the most dangerous health experiment humans have ever run. We explored how food acts as information—shaping gene expression, immune health, and even how full or satisfied you feel. Dr. Bland, often called the father of functional medicine, brings decades of insight into how modern food systems are quietly rewriting our biology. Dr. Jeffrey Bland is known as the father of functional medicine and has spent over five decades studying how food, lifestyle, and biology shape human health. He’s a prolific educator, researcher, and founder behind multiple institutes, including Big Bold Health, dedicated to personalized and preventive medicine. What you’ll learn: (02:44) Why ultra-processed foods may be the biggest driver of modern chronic disease. (04:32) How food functions as biological information that influences gene expression. (06:49) Why life expectancy is declining despite advances in modern medicine. (09:22) How ultra-processed foods disrupt the gut microbiome and immune system. (17:38) What distinguishes healthy gut bacteria from harmful microbial patterns. (24:39) Why poor satiety from processed foods fuels weight gain and GLP-1 drug use. (28:29) How bitter compounds in natural foods naturally stimulate satiety hormones. (39:39) One simple mindset shift that can immediately improve food choices and health. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/bold → Fatty15 | Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness - especially as you age. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/VIRGINWELLNESS and using code VIRGINWELLNESS at checkout. Learn more about your ad choices. Visit megaphone.fm/adchoices

Midlife isn't a crisis; it's a catalyst. On Well Beyond 40, JJ Virgin guides a conversation about rewriting the narrative of aging for women, moving from simply coping to truly thriving. This isn't about chasing youth, but about building a foundation of strength and vitality that makes the coming decades the most rewarding yet. Each episode feels like a direct, practical talk with a trusted expert who cuts through the noise. You'll hear actionable strategies rooted in science, focusing on how nutrition, movement, and mindset intersect uniquely during this life stage. JJ translates complex research into clear steps for refueling your body, managing energy, and cultivating a sense of purpose that goes far beyond the scale. The Well Beyond 40 podcast operates on the principle that knowing *why* something works is just as important as knowing *what* to do. Listeners are invited into a space where questions about metabolic shifts, hormonal balance, sustainable fitness, and intentional beauty are met with evidence-based answers and genuine empathy. It’s a resource for any woman ready to move past generic advice and discover what it means to age with power, confidence, and joy on her own terms. Tune in to reframe your approach and build a life that feels truly well-lived.
Author: Language: English Episodes: 100

Well Beyond 40
Podcast Episodes
The Truth About Keeping Weight Off (Why Most People Fail!) [not-audio_url] [/not-audio_url]

Duration: 43:13
Your body is wired for survival, not aesthetics, and the moment you lose weight, it fights back with everything it's got. I've seen too many women in their 40s, 50s, and beyond lose significant weight only to watch it cr…
Detoxify Your Life Without Losing Your Mind with Dr. Aly Cohen [not-audio_url] [/not-audio_url]

Duration: 58:32
"Chemicals are actually more dangerous at low doses than high ones... they're small amounts, but they're able to do a lot with the size and concentration and power of what they are." – Dr. Aly Cohen I invited back triple…
Reclaiming Your Sexual Power After 40 with Susan Bratton [not-audio_url] [/not-audio_url]

Duration: 54:24
"Passionate lovemaking is a mindfulness practice. Even for me now, I have to get in there, connect with my husband, and focus on sensation." – Susan Bratton I sat down with my longtime friend Susan Bratton, intimacy expe…
Can You Really Boost Your Metabolism? (What Actually Works) [not-audio_url] [/not-audio_url]

Duration: 20:28
I'm pulling back the curtain on metabolism myths and sharing what really works for women navigating midlife changes. The truth is, your metabolism isn't simply "fast" or "slow" - it's a complex system where small adjustm…
What to Do if Your Compounded GLP-1 Goes off the Market [not-audio_url] [/not-audio_url]

Duration: 20:45
Many women in midlife are discovering that GLP-1 medications like Ozempic and Wegovy have been game-changers for improving metabolic health—but what happens when these medications become unavailable or too expensive? I'm…
Are You Afraid of Carbs?? Here’s Why Women Over 60 Need Carbs! [not-audio_url] [/not-audio_url]

Duration: 19:24
I'm busting a major myth today that's holding back so many women in their quest for health after 60: the idea that carbs are the enemy. While diet dogmas like keto and carnivore have vilified carbohydrates, I'm sharing w…

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