In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation.
Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear.
You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future.
In This Episode:
00:00 Amyloid Myth Busted
00:15 Show Intro and Guest
04:18 Book Inspiration Microglia
06:02 Symptom Care vs Root Cause
09:51 Microglia M1 vs M2
11:15 Gut Brain Inflammation Link
15:01 Metabolism Mirrors Microglia
17:57 Infections Vaccines and Triggers
19:31 CTE Diabetes and Feedforward
25:20 New Tools and Beta Amyloid Drugs
30:37 Cochrane Verdict Drugs Fail
33:28 Lifestyle Trial Reverses Decline
38:23 Microglia Lifestyle Levers
39:07 Exercise Myokines Brain Boost
42:20 Alzheimers Risk Epigenetics
45:12 Imaging Microglia TSPO
46:24 Fasting Ketones Brain Fuel
49:45 MCT Oil Memory Care
51:16 POINTER Lifestyle Trial
55:57 Fiber Polyphenols Foods
58:34 Supplements DHA Vitamin D
01:02:23 Key Labs Glucose Tau
01:06:19 Prevention Mission Wrap
01:07:43 Final Thanks Outro
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"Exercise isn't just changing your body. It's changing the environment inside your brain."
Tune into Dr. Jockers Functional Nutrition for conversations that bridge the gap between complex science and practical, daily health choices. Hosted by Dr. David Jockers, a Doctor of Natural Medicine and Functional Nutritionist, this podcast delves into the underlying causes of health challenges rather than just treating symptoms. You’ll hear detailed discussions on metabolic flexibility, the intricacies of gut health, and sustainable methods for reducing systemic inflammation. Dr. Jockers draws from his clinical experience and research, which has been featured in media like ABC and The Dr. Oz Show, to break down strategies for improving brain function, supporting the immune system, and achieving natural detoxification. Each episode is built on a foundation of evidence, yet presented in a way that feels accessible, whether you're deeply invested in fitness or simply seeking a more vibrant life. The focus here is on providing actionable knowledge-the kind that empowers you to make informed decisions about nutrition and lifestyle. This isn't about quick fixes; it's about understanding how your body works and learning the principles that can help it thrive for the long term.
Author: Dr. Jockers
Language: English
Episodes: 50
In this episode, Dr. David Jockers breaks down the single most dangerous medication that millions of people take every day without realizing the risks: proton pump inhibitors (PPIs), commonly prescribed for acid reflux u…
In this episode, Dr. David Jockers walks you through a complete 14-day progressive fasting protocol built specifically to burn visceral fat, the inflammatory fat that wraps around your liver, pancreas, heart, and intesti…
In this episode, Dr. David Jockers sits down with Dr. Sara Pugh, who holds a PhD in molecular mechanisms and was the first board-certified quantum biologist, for a conversation about the health input almost nobody is opt…
In this episode, Dr. David Jockers breaks down the seven daily habits silently fueling the surge in Alzheimer's, dementia, and other neurodegenerative conditions, and lays out exactly how to reverse each one before sympt…
In this episode, Dr. David Jockers goes solo to break down the 10 everyday foods quietly wrecking your metabolism, and exactly what to swap them for. From table salt and seed oils to soy, processed meat, microwaved popco…
In this episode, Dr. David Jockers sits down with Vanessa Spina, sports nutrition specialist, bestselling author of Keto Essentials, creator of the Tone ketone breath analyzer, and host of the Optimal Protein Podcast, fo…
In this episode, Dr. David Jockers breaks down fasting as the most powerful natural anti-inflammatory tool available, walking through a detailed hour-by-hour timeline of what happens inside your body, from the first 12-h…
In this episode, Dr. David Jockers goes solo to break down five of the most common health myths he hears on a regular basis, the ones most people you know believe and are unknowingly putting into practice against their o…
In this episode, Dr. David Jockers is joined by his longtime friend Dr. Josh Axe, co-founder and chief visionary officer of Ancient Nutrition, founder of draxe.com, and founder of The Health Institute, for a deep dive in…
In this episode, Dr. David Jockers breaks down the science behind five simple drinks that clear your arteries, reduce inflammation, and support long-term cardiovascular health, walking through the human research behind e…
