In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation.
Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear.
You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future.
In This Episode:
00:00 Amyloid Myth Busted
00:15 Show Intro and Guest
04:18 Book Inspiration Microglia
06:02 Symptom Care vs Root Cause
09:51 Microglia M1 vs M2
11:15 Gut Brain Inflammation Link
15:01 Metabolism Mirrors Microglia
17:57 Infections Vaccines and Triggers
19:31 CTE Diabetes and Feedforward
25:20 New Tools and Beta Amyloid Drugs
30:37 Cochrane Verdict Drugs Fail
33:28 Lifestyle Trial Reverses Decline
38:23 Microglia Lifestyle Levers
39:07 Exercise Myokines Brain Boost
42:20 Alzheimers Risk Epigenetics
45:12 Imaging Microglia TSPO
46:24 Fasting Ketones Brain Fuel
49:45 MCT Oil Memory Care
51:16 POINTER Lifestyle Trial
55:57 Fiber Polyphenols Foods
58:34 Supplements DHA Vitamin D
01:02:23 Key Labs Glucose Tau
01:06:19 Prevention Mission Wrap
01:07:43 Final Thanks Outro
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"Exercise isn't just changing your body. It's changing the environment inside your brain."
Tune into Dr. Jockers Functional Nutrition for conversations that bridge the gap between complex science and practical, daily health choices. Hosted by Dr. David Jockers, a Doctor of Natural Medicine and Functional Nutritionist, this podcast delves into the underlying causes of health challenges rather than just treating symptoms. You’ll hear detailed discussions on metabolic flexibility, the intricacies of gut health, and sustainable methods for reducing systemic inflammation. Dr. Jockers draws from his clinical experience and research, which has been featured in media like ABC and The Dr. Oz Show, to break down strategies for improving brain function, supporting the immune system, and achieving natural detoxification. Each episode is built on a foundation of evidence, yet presented in a way that feels accessible, whether you're deeply invested in fitness or simply seeking a more vibrant life. The focus here is on providing actionable knowledge-the kind that empowers you to make informed decisions about nutrition and lifestyle. This isn't about quick fixes; it's about understanding how your body works and learning the principles that can help it thrive for the long term.
Author: Dr. Jockers
Language: English
Episodes: 50
In this episode, Dr. Jockers explores the many ways castor oil can support your health, from improving liver and gallbladder function to promoting lymphatic drainage and better tissue circulation. You'll learn why castor…
In this episode, Dr. David Jockers explores why many people struggle to burn fat despite eating well and exercising. You'll discover how your metabolic environment, circadian rhythm, and meal timing influence fat storage…
In this episode, Dr. Jockers sits down with Dr. Jason Fung to explore why fat loss is not just about calories, but about understanding hunger, hormones, and the body's fat thermostat. You'll learn how insulin, cravings,…
In this episode, Dr. Jockers reveals the science behind detoxing seed oils, how damaged fats can impact your mitochondria, and why removing these fats from your cells may take longer than expected. You'll learn how fasti…
In this episode, Dr. David Jockers breaks down what happens inside your body during a 30-hour fast, including fat burning, ketone production, gut health improvements, and the cellular repair processes activated during fa…
In this episode, Dr. Jockers sits down with Ben Azadi to break down why improving your metabolic health is the real key to lasting fat loss. You'll discover why counting calories often backfires, how ketosis actually wor…
In this episode, Dr. Jockers reveals how cold water exposure can activate your mitochondria, support fat burning, and increase energy production. You'll learn why this ancient stressor can help your body become more resi…
In this episode, Dr. Jockers explains what zombie cells are, how they contribute to aging, inflammation, and chronic disease, and why clearing them out may be one of the most effective ways to improve your health. You'll…
In this episode, Dr. Jockers sits down with holistic dentist Dr. Michelle Jorgensen to explore why cavities aren't simply a result of sugar or poor brushing. You'll discover how your oral health reflects what's happening…
In this episode, Dr. Jockers reveals his proven five-step process for breaking the "lock" on fat burning by improving insulin sensitivity, supporting metabolic health, and helping your body access stored energy more effe…
