In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation.
Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear.
You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future.
In This Episode:
00:00 Amyloid Myth Busted
00:15 Show Intro and Guest
04:18 Book Inspiration Microglia
06:02 Symptom Care vs Root Cause
09:51 Microglia M1 vs M2
11:15 Gut Brain Inflammation Link
15:01 Metabolism Mirrors Microglia
17:57 Infections Vaccines and Triggers
19:31 CTE Diabetes and Feedforward
25:20 New Tools and Beta Amyloid Drugs
30:37 Cochrane Verdict Drugs Fail
33:28 Lifestyle Trial Reverses Decline
38:23 Microglia Lifestyle Levers
39:07 Exercise Myokines Brain Boost
42:20 Alzheimers Risk Epigenetics
45:12 Imaging Microglia TSPO
46:24 Fasting Ketones Brain Fuel
49:45 MCT Oil Memory Care
51:16 POINTER Lifestyle Trial
55:57 Fiber Polyphenols Foods
58:34 Supplements DHA Vitamin D
01:02:23 Key Labs Glucose Tau
01:06:19 Prevention Mission Wrap
01:07:43 Final Thanks Outro
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"Exercise isn't just changing your body. It's changing the environment inside your brain."
Tune into Dr. Jockers Functional Nutrition for conversations that bridge the gap between complex science and practical, daily health choices. Hosted by Dr. David Jockers, a Doctor of Natural Medicine and Functional Nutritionist, this podcast delves into the underlying causes of health challenges rather than just treating symptoms. You’ll hear detailed discussions on metabolic flexibility, the intricacies of gut health, and sustainable methods for reducing systemic inflammation. Dr. Jockers draws from his clinical experience and research, which has been featured in media like ABC and The Dr. Oz Show, to break down strategies for improving brain function, supporting the immune system, and achieving natural detoxification. Each episode is built on a foundation of evidence, yet presented in a way that feels accessible, whether you're deeply invested in fitness or simply seeking a more vibrant life. The focus here is on providing actionable knowledge-the kind that empowers you to make informed decisions about nutrition and lifestyle. This isn't about quick fixes; it's about understanding how your body works and learning the principles that can help it thrive for the long term.
Author: Dr. Jockers
Language: English
Episodes: 50
In this episode, Dr. David Jockers lays out the exact insulin resistance healing protocol he's used to help thousands of people restore metabolic health, sometimes in as little as a week, and almost always within a few m…
In this episode, Dr. David Jockers sits down with fasting expert Ben Azadi, host of the Metabolic Freedom Podcast and author of the book Metabolic Freedom, for a detailed, hour-by-hour walk through exactly what happens i…
In this episode, Dr. Jockers breaks down the common and often overlooked signs of vitamin B12 deficiency, including fatigue, brain fog, nerve pain, premature graying, and sulfite sensitivity. You'll learn why B12 is so i…
In this episode, Dr. Jockers breaks down why optimal nutrition isn't about following one specific diet, but creating a personalized real food approach that works with your body. You'll learn the foundational principles h…
In this episode, Dr. Jockers explores the role of the vagus nerve and why improving vagal tone can support digestion, stress regulation, sleep, and overall healing. You'll learn how this important nerve connects your bra…
In this episode, Dr. Jockers reveals the most effective strategies to target visceral fat by understanding the role of insulin, cortisol, fasting, and metabolic health. You'll learn why belly fat can be resistant to trad…
In this episode, Dr. Jockers sits down with neuroscientist and psychiatrist Dr. Dave Rabin to explore why chronic stress can keep your nervous system stuck in survival mode. You'll learn what happens in the brain and bod…
In this episode, Dr. Jockers explores the root causes of acne and skin inflammation, revealing how the gut-liver-skin axis plays a major role in skin health. You'll learn why addressing internal imbalances, inflammation,…
In this episode, Dr. Jockers reveals the number one gut-healing strategy that supports a healthier microbiome, reduces gut issues like gas, bloating, parasites, and constipation, and explains why mitochondrial function i…
In this episode, Dr. Jockers sits down with Dr. Jaban Moore to explore how mold, pathogens, and heavy metals can quietly impact your energy, immune system, and long-term health. You'll learn why some people are more susc…
