Your Best Shot: Holistic Approach to GLP-1

Your Best Shot: Holistic Approach to GLP-1

Author: Functional Forum February 23, 2026 Duration: 36:12

In this episode of The Evolution of Medicine, host James Maskell interviews registered dietitian Ashley Koff about her new book Your Best Shot. The conversation explores the seismic impact of GLP-1 agonists like Ozempic and Wegovy—and how functional medicine can pivot from a "weight loss" mindset to a "weight health" approach.

Koff reframes these medications not as magic bullets, but as biosimilar hormone replacement tools that "switch on" receptor sites—without repairing the underlying ecosystem. She outlines a five-part Weight Health Hormone assessment and introduces a Physician–Dietitian–Health Coach triad to ensure sustainable outcomes.

The episode challenges practitioners to stay "agnostic about the agonist" and instead focus on metabolic repair, patient education, and structured team-based care.

 

About the Guest:

Ashley Koff, RD is a registered dietitian and functional nutrition expert focused on metabolic health, personalized nutrition, and hormone signaling. She is the author of Your Best Shot and advocates for a "Weight Health" approach that integrates assessment, repair, and team-based implementation.

 

Ashley Koff, RD

Website: https://thebetternutritionprogram.com/your-best-shot/#Order?utm_source=ig&utm_medium=social&utm_content=link_in_bio&fbclid=PAZXh0bgNhZW0CMTEAc3J0YwZhcHBfaWQMMjU2MjgxMDQwNTU4AAGn0Q9_BL_AVS4TE9ropSLtTkwP2y5sIOqKsbxZaaKPv3nNMm0Tq8QuWidcGUk_aem_U9Z5knW9eqsiMjw19fzflA 

Instagram: https://www.instagram.com/ashleykoffapproved/?hl=en

Facebook: https://www.facebook.com/ashleykoffapproved/

Linkedin: https://www.linkedin.com/in/ashley-koff/

 

James Maskell

Website: https://www.jamesmaskell.com/

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

LinkedIn: https://www.linkedin.com/in/jamesmaskell

Thank you for listening.

Please subscribe and share.

This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

https://drtalks.com/podcast-service/


Hosted by the Functional Forum, Evolution of Medicine Podcast sits at the intersection of health, fitness, and alternative approaches to well-being. It’s a space for conversations that go beyond conventional treatment, exploring the ideas and practitioners actively reshaping how we think about care. Each episode features in-depth discussions with clinicians, researchers, and thought leaders who are redefining the patient journey. You’ll hear practical insights into functional medicine, preventative strategies, and the nuanced connections between lifestyle, nutrition, and long-term health. This podcast digs into the real-world application of these evolving principles, offering listeners a forward-looking perspective on what it means to truly support the body's innate capacity for healing. Tune in for a thoughtful exploration of the systems, science, and stories driving this shift, providing a valuable resource for both healthcare professionals and anyone invested in taking a more active role in their own wellness. The dialogue here is dedicated to understanding the full spectrum of what modern medicine can become.
Author: Language: English Episodes: 100

Evolution of Medicine Podcast
Podcast Episodes
The Unity of Metabolic and Mental Health [not-audio_url] [/not-audio_url]

Duration: 43:24
Robert Lustig, MD joins James for this information-packed episode that unifies mental and metabolic healthcare. Dr. Lustig is a pediatric endocrinologist and food educator, who focuses on spreading awareness about the to…
The Best Healthcare System in the World [not-audio_url] [/not-audio_url]

Duration: 37:59
In this episode, Darrell Moon, founder of Aspirational Healthcare, discusses the Nuka System of Care in Anchorage, Alaska, which has been called "the best healthcare system in the world." The system is built around the n…
Cardiometabolic Disease, Fatty Liver & Weight Loss [not-audio_url] [/not-audio_url]

Duration: 31:40
In this episode James Maskell is joined by returning guest, Dr. Shilpa Saxena, MD to continue exploring the use of GLP-1 agonists, specifically Semaglutide, for weight loss and cardiometabolic diseases. The conversation…
VagusFest Debut [not-audio_url] [/not-audio_url]

Duration: 25:18
In James Maskell's first-ever solo podcast, he introduces Evolution of Medicine's upcoming event, VagusFest. On May 29, 2024, listeners can join the Evolution of Medicine's debut VagusFest, a participatory education expe…
Cleveland Clinic Functional Medicine Update [not-audio_url] [/not-audio_url]

Duration: 26:24
Dr. James Carter, the director of the Center for Functional Medicine at Cleveland Clinic, discusses his journey to functional medicine and his role at Cleveland Clinic. Dr. Carter is also a vascular medicine specialist a…
Anthroposophic Medicine [not-audio_url] [/not-audio_url]

Duration: 39:26
In this episode, we learn about anthroposophic medicine from James Maskell's guest, Adam Blanning, MD. Anthroposophic medicine takes a holistic approach to humans, nature, illness, and healing by addressing the physical,…
Toxicity in Children: Protecting Future Generations [not-audio_url] [/not-audio_url]

Duration: 42:50
James Maskell's guest on this episode is Dr. Elisa Song, a holistic pediatrician whose mission is to educate clinicians and parents alike about environmental toxicity in children and how to help children thrive by improv…
Clearing Confusion Around Botanical Medicine with Dr. Guilliams [not-audio_url] [/not-audio_url]

Duration: 49:44
In this episode, Dr. Tom Guilliams rejoins the podcast to explore the complexities and misconceptions surrounding botanical medicine and how clinicians can maximize the therapeutic effects of herbs. We learn from Dr. Gui…
The Vagus Nerve: The Organ of Unity [not-audio_url] [/not-audio_url]

Duration: 46:17
In this podcast episode, James Maskell interviews Dr. Navaz Habib about the importance of the vagus nerve in healing and overall health. Dr. Habib explains that the vagus nerve plays a critical role in shifting the body…