Aging is best explained by declining mitochondrial function over time.

Aging is best explained by declining mitochondrial function over time.

Author: Chris Masterjohn, PhD December 9, 2025 Duration: 3:16
 
Aging is best explained by declining mitochondrial function over time.
 
This answers its own "why."
 
Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost.
 
But how much is under your control.
 
From Joe Rogan Experience JRE 2420.
 
It's a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order.
 
Hence, there will always be slippage, but how much slippage depends on genetics, environment, and behavior, and all slippage leads to loss of mitochondrial repair, which itself directly causes the loss of repair capacity as it weakens the defense against the imperative of the second law of thermodynamics.

Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
High-Dose Riboflavin for Migraines | Chris Masterjohn Lite #152 [not-audio_url] [/not-audio_url]

Duration: 7:58
Got migraines? 😣 You may need a LOT of riboflavin! 😮 This episode covers what dose to use, and how to time the dosing. This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that…
Riboflavin for Iron-Deficiency Anemia | Chris Masterjohn Lite #151 [not-audio_url] [/not-audio_url]

Duration: 7:01
Got anemia? 🙋🏽🙋🏼‍🙋‍♀️🙋🏿‍♀️ You may need more riboflavin! 😮 This episode covers how to know if your iron-deficiency anemia could be helped by riboflavin, and what to do about it using food and supplements. This episode is…
The Best Blood Test for Riboflavin | Chris Masterjohn Lite #149 [not-audio_url] [/not-audio_url]

Duration: 6:25
This episode covers the best blood test to use for assessing riboflavin status. This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that covers the basics of each nutrient, in…
How to Get Enough Riboflavin From Food | Chris Masterjohn Lite #148 [not-audio_url] [/not-audio_url]

Duration: 10:35
Here's how to get RIBOFLAVIN from FOOD. 🍲 😋 This episode covers how to figure out how much you need, and which foods to get it from. This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-d…
Exercise and Dieting Make You Need More Riboflavin | Chris Masterjohn Lite #147 [not-audio_url] [/not-audio_url]

Duration: 7:12
Losing weight? Leaning out? Slimming down? 🙋🏽🙋🏼‍♂️🙋‍♀️🙋‍♂️🙋🏿‍♀️ Hitting the gym? Doing cardio? Gettin' yo fat-burnin' on? 🙋🏽🙋🏼‍♂️🙋‍♀️🙋‍♂️🙋🏿‍♀️ You might need more riboflavin. 😬 This episode covers by how much, and how to…